Ajay AdhikareeNepal, Nepal
Title: Global longitudinal strain measured by 2d speckle tracking echocardiography in stable angina patients and their coronary angiogrpahic correlation
Introduction: Myocardial strain assessed by speckle tracking echocardiography quantifies myocardial deformation which appears earlier than wall motion abnormality. Thus global longitudinal strain assesses myocardial function in early stage of ischemic evolution.
Objective: This study measured global longitudinal strain by 2D speckle tracking echocardiography in stable angina patients. Specifically, this study determined correlation of global longitudinal strain with coronary angiography and diagnostic accuracy of global longitudinal strain for detection of presence and severity of coronary artery disease.
Methodology: This was a descriptive cross-sectional study which included 89 patients without regional wall motion abnormality who were otherwise indicated to undergo coronary angiography at National Academy of Medical Sciences / Shahid Gangalal National Heart Center, Kathmandu, Nepal over a period of 12 months (July 2018 to June 2019).
Results: There was a strong negative correlation (r = -0.824) between global longitudinal strain value and presence of significant coronary artery disease. The sensitivity, specificity and area under curve for global longitudinal strain value of ? -18.5 for identifying significant coronary artery disease was 96.8%, 85.2% and 0.937 respectively (P<0.001). The mean values of global longitudinal strain for single vessel disease, double vessel disease and triple vessel disease were respectively -15.94 ± 7.30, -15.28 ± 0.58 and -11.59 ± 1.35 (P <0.001).
Conclusion: Global longitudinal strain is a sensitive, specific and excellently accurate modality of investigation that has strong negative correlation with presence and severity of significant coronary artery disease.
After completion of doctorate of medicine (cardiology) in 2019, Dr. Adhikaree is currently affiliated with Devdaha Medical College & Research Institute, Rupandehi, Nepal as an assistant professor. He has wide field of interest involving both interventional as well as preventive cardiology. As a socially responsible and technically competent doctor, he was awarded the "Young Scientist Award (Cardiology) 2019" by Nepal Heart Foundation. He has about a dozen of publications in his name and had attended various national and international conferences and seminars.