Virtual Conference
Heart 2022 Conference

Arik Eisenkraft

The Hebrew University Faculty of Medicine, Israel

Title: 24-hour Ambulatory Blood Pressure Measurement using a Novel Non-Invasive, Cuff-less, Wireless Device


Ambulatory blood pressure monitoring (ABPM) using cuff-based devices is used for diagnosis and treatment of hypertension. Technical limitations, low compliance and complex procedures limit their use. The aim of the present study was to test the accuracy of a new photoplethysmography (PPG)- based, wearable device (Wrist-monitor) as compared to the standard cuff-based ABPM device. 24H ABPM was performed in parallel for both devices on volunteers aged 65-18 years, while documenting their daily activities. Level of comfort and activity disturbance of both devices were recorded. Linear regression and BlandAltman were used to evaluate the agreement between devices. Receiver Operating Characteristic (ROC) curve analysis was used to classify hypertension based on the average Wristmonitor measurements as compared to a cuff-based ABPM device. The study included 28 subjects (18 men) mean age 41.5±16.2 years. Bland-Altman analysis resulted in 24H bias of -1.1 mmHg for both diastolic blood pressure (DBP) and systolic blood pressure (SBP). Mean daytime bias was -1.9 mmHg for DBP and SBP, while nighttime bias was smaller (0.7 and 0.4 mmHg for DBP and SBP respectively). ROC curve analysis yielded a mean area under the curve (AUC) of 1 for SBP and 24H BP measurements. AUCs of 0.994 and 0.955 were found for the daytime DBP and night DBP, respectively. 24H ABPM with the Wrist-monitor caused significantly less inconvenience compared to the cuff-based device (p<0.001). The cuff-less device provides comparable measurements to those obtained with the currently used cuff-based ABPM device, with significantly less inconvenience to the subject


Prof. Arik Eisenkraft retired from the IDF Medical Corps in 2016 as a LTC after 20 years of service in R&D units, mainly focussing on acute trauma care, CBRN Medicine, and medical response to mass casualty events. In 2013, he established the Institute for Research in Military Medicine, a joint research institute to the Hebrew University Faculty of Medicine, Jerusalem, and the IDF Medical Corps, where he still conducts research on acute care. Prof. Eisenkraft has joined Biobeat Technologies LTD. in 2017 as the Chief Medical Officer, leading its pre-clinical and clinical efforts.