Virtual Conference
Heart 2022 Conference

Ede Frecska

Debrecen University, Hungary

Title: The protective role of dimethyltryptamine and its analogues against ischemia-reperfusion injury


The vast majority of research on dimethyltryptamine (DMT) has targeted its psychotropic properties and serotonergic activity, with little focus on its effects beyond the nervous system and at other receptor sites. The recent discovery that DMT is an endogenous agonist of the sigma-1 receptor (sigmaR-1) may shed light on yet undiscovered physiological and therapeutic mechanisms of DMT action. Since the sigmaR-1 has an extensive role in mitigation of several forms of intracellular stress such as mitochondrion, endoplasmic reticulum, and oxidative stress, as well as protecting against apoptotic cell death and regulating immune processes, one may suppose similar effects from DMT administration.
In this presentation, we briefly overview the function of sigmaR-1 in cellular bioenergetics with a focus on the processes involved in ischemia-reperfusion injury (IRI) and summarize the results of our in vitro and in vivo studies. IRI is a complex phenomenon with mechanisms underlying organ transplantation, stroke, myocardial infarct, general brain hypoxia, cardiovascular surgery, neonatology, and cardiopulmonary resuscitation. We conclude that the effect of DMT may extend beyond central nervous system activity and involve a universal role in cellular protective mechanisms suggesting therapeutic potentials against different types of cardiac IRI-s


Ede Frecska, M.D., Ph.D. has finished medical school in 1977, received board certification from psychiatry and clinical pharmacology in 1986 and 1987 (respectively), and completed his Ph.D. in 2006 from Semmelweis University, Hungary. He is the acting chief of psychiatry at University of Debrecen, Hungary. He had 17 years research experience and clinical practice in the USA, has over 150 publications that have been cited more than 2000 times, and his publication h-index is 23. He has been serving as an editorial board member of several professional journals.