Mevul SrivastavaInstitute of Health Informatics Research, United Kingdom
Title: Ultrafiltration for acute heart failure
Background: Pvarmacotverapies such as loop diuretics are the cornerstone treatment for acute heart failure (AHF), but resistance and poor response can occur. Ultrafiltration (UF) is an alternative therapy to reduce congestion, however, its benefits, efficacy, and safety are unclear.
Objectives: To assess the effects of UF compared to diuretic therapy on clinical outcomes sucv as mortality and rehospitalization rates.
Search methods: We undertook a systematic search in June 2021 of the following databases: CENTRAL, MEDLINE, Embase, Web of Science CPCI-S, and ClinicalTrials.gov.
Selection criteria: We included randomized controlled trials (RCTs) that compared UF to diuretics in adults with AHF.
Data collection and analysis: Two review authors independently assessed trial quality and extracted data. We contacted study authors for any further information, and language interpreters to translate texts. We assessed the risk of bias in included studies using the Risk of Bias 2 (RoB2) tool and assessed the certainty of the evidence using GRADE.
To be updated soon...