Romero Henrique de Almeida BarbosaFederal University of San Francisco Valley (UNIVASF), Brazil
Title: Vitamin D and cardiovascular prevention
The issue of vitamin D and cardiovascular prevention remains controversial. Vitamin D deficiency is a risk factor for the development of endothelial dysfunction. In other hand, several studies have investigated the usefulness of supplementation with vitamin D and its analogues for treatment and prevention of conditions such as hypertension, myocardial infarction and cerebrovascular disease. One of the most important actions is related to calcium homeostasis. Activation of vitamin D receptors on endothelial cells triggers the expression of vascular endothelial growth factor (VEGF) which in turn acts on its receptors and alters relevant cellular activities, such as cell proliferation and survival and vascular permeability. VEGF signaling is also involved in several cardiovascular diseases (CVD). The active form of vitamin D can be synthesized in endothelial cells by the activity of specific ?-hydroxylase. The 1,25(OH2) D3 product acts on inflammatory mediators, modulating the activity of immune system cells such as macrophages, monocytes and B and T lymphocytes. In addition, exposure of the active form of vitamin D to endothelial cells reduces the expression of pro-inflammatory substances, such as IL-1?, which is inversely related to normal endothelial function. There are suggestions for a role of vitamin D in CVD in ecological studies, with an increase in heart disease events with geographic latitude, that is, associated with less exposure to sunlight, with vitamin D concentration decreasing with latitude. However, despite observational studies demonstrating low concentrations of 25-hydroxyvitamin D positively associated with the risk of cardiovascular events. Although it is an exciting topic to evaluate regular use in specific pollutions, there are still no recommendations within several guidelines on cardiovascular prevention for its regular supplementation to be indicated.
Graduated in Medicine from the Faculty of Medical Sciences of the University of Pernambuco concluded in December 1998. Medical residency in Internal Medicine at the Oswaldo Cruz University Hospital-FCM/UPE. Medical residency in Cardiology by the Foundation for the Encouragement of Teaching and Research in Cardiology (FUNCORDIS). Specialist title in Cardiology by the Brazilian Society of Cardiology (SBC/AMB) with certification in the areas of: Ergometry and Echocardiography. Postgraduate in Fetal Echocardiography by the Lilian Lopes Institute of ECOKIDS-SP. Cardiologist and Technical Director of the San Francisco Medical Institute Paulo Afonso-BA. Master Professor of Cardiology at the Federal University of San Francisco Valley (UNIVASF), Campus Paulo Afonso-BA. Coordinator of the Collegiate Board of the Paulo Afonso-BA Medicine Course at UNIVASF from August 2015 to October 2019, currently acting as Vice Coordinator of the Medical Internship of the Paulo Afonso-BA Medicine Course at UNIVASF. Student of the Doctoral course of the Postgraduate Program in Biology Applied to Health at the Federal University of Pernambuco.