Sergiy LozinskyVinnytsia Pirogov Memorial National Medical University, Ukraine
Title: Heart Remodeling and CYP11B2 Polymorphism in Hypertensive Males
It was shown that hypertensive heart remodeling could be partially related to the polymorphism of the CYP11B2 gene which is responsible for the aldosterone synthase activity. The purpose of this study was to assess the association of polymorphism of the CYP11B2 gene with structural remodeling by changes in geometry and myocardial density.
Methods: The study involved 150 men aged 45-60 with and without essential hypertension (EH), who possessed no irreversible target organ damage. Fifty of them had normal BP, 58 had EH without left ventricular hypertrophy (LVH) and 42 had EH and LVH. Each participant underwent office blood pressure measurement, echocardiography with echo-reflectivity analysis, and determination of the C-344T polymorphism of the CYP11B2 gene.
Results: Patients with EH and LVH differed not only by LV mass but also by larger body mass, relative wall thickness, and wider echo-reflectivity spectrum. The associations of larger end-diastolic diameter with the C allele, and the larger thickness of the posterior wall and interventricular septum with the T allele, were revealed only in patients with EH and LVH.
Conclusions: Hypertensive patients with LVH are likely to be a distinct cluster with their genetic predisposition to hypertensive heart disease
Sergiy Lozinsky graduated from Vinnytsia Pirogov Memorial National Medical University in 1992. In 2001 he completed his Ph.D. degree and occupied the position of Assistant Professor at Vinnytsia Pirogov Memorial National Medical University, Ukraine. In 2018 he completed a Doctor of Medical Sciences degree and now he is a Professor in the Department of Internal Medicine at Vinnytsia Pirogov Memorial National Medical University, Ukraine. He has over 50 publications.