Objective: Our aim was to assess the correlation between atherogenic index of plasma (AIP) and spontaneous reperfusion (SR) in patients with ST elevation myocardial infarction (STEMI) and also to evaluate its relationship with in-hospital & mid-term outcomes.

Methods: Our study included 259 STEMI patients. AIP was calculated from the lipid profile of all participants who underwent coronary angiography. SR was defined as the achievement of grade 3 TIMI flow in the infarct-related artery (IRA) before PCI. We categorized patients into an SR group [57 (22%)] and a non-SR group [202 (78%)]. The Gensini scoring system was used to evaluate the severity of coronary artery disease.  

Results: The AIP value was higher in the Non-SR group than in the SR group [0.71 ± 0.11 vs. 0.56 ± 0.03; p <0 .001]. AIP had a positive correlation (0.53, P<0.001) with the severity of CAD. The in-hospital and mid-term adverse outcomes were lower in patients with SR. AIP was found to be correlated with diabetes, hs-C-reactive protein, BNP, LA volume index, and E/e'. Furthermore we observed that AIP was the strongest independent predictor for non-SR in STEMI patients. The cut-off value of AIP for predicting non-SR was >0.61 (AUC: 0.89). 

Conclusion: Lower AIP is associated with the development of SR in STEMI patients. AIP was positively correlated with the severity of CAD. High AIP is also associated with adverse outcomes. We found that a higher AIP value was an independent predictor of non-SR. Hence, AIP could be advocated for routine measurement in clinical practice.

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