Achu Achiri Roosevelt

University of Yaoundé, Cameroon

Title: Increased risk of arterial stiffness in Rhumatoid arthritis patients in a Subsahran African setting

Abstract

Background: Analysis of arterial stiffness (AS) is a good marker of early arterial disease and an important determinant of cardiovascular risk independent of other traditional cardiovascular risk factors. Carotid-femoral pulse wave velocity (CfPWV) is the gold standard to evaluate arterial stiffness. There is evidence that patients with rheumatoid arthritis (RA) have a higher arterial stiffness than their age-matched healthy counterparts and thus have higher cardiovascular (CV) risk. However, data on arterial stiffness in African rheumatoid arthritis patients is scarce.

Objectives: To determine the patterns of arterial stiffness in rheumatoid arthritis patients in a sub-saharan African setting, using CfPWV and Augmentation index (AIx).

Method: We conducted a case-control study, over four months on 63 subjects among which 31 RA patients matched for age and sex with 32 healthy subjects. AIx and CfPWV were determined non-invasively by radial pulse wave analysis and Carotid femoral wave analysis respectively, using a sphygmocor Atcor device (SphygmoCor, PWV Medical, Sydney, Australia).

Results: The mean age of RA patients was 47±14 years with most of them being females (n=26, 83.9%). CfPWV was significantly higher in RA patients compared to the control group (mean: 8.85 ± 2.1 vs 7.45 ± 1.38; p= <0.01) as well as was AIx (Median: 33[26-43] vs 26[20-31]; p=0.01). RA (OR:6.105; 95%CI:1.52-24.54; P<0.01), Diabetes (OR:1.34; 95%CI:1.14-5.17; P=0.05), elevated CRP levels (OR:4.01; 95%CI:1.16-13.68; P=0.03) and Hypertension (OR:5.75; 95%CI:1.24-11.60; P<0.01) were independent determinants of arterial stiffness.

Conclusion: Arterial stiffness, a well-recognized marker of cardiovascular risk is increased among patients suffering from rheumatoid arthritis when compared to a healthy control group.

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4th International Conference on Cardiology

Achu Achiri Roosevelt

Title: Increased risk of arterial stiffness in Rhumatoid arthritis patients in a Subsahran African setting

Abstract

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