Anuhya Katta
University of Perpetual Help System Dalta, PhilippinesPresentation Title:
Impact of hypertensive disorders of pregnancy on cognitive functioning of the offspring
Abstract
Globally, one of the main causes of maternal and fetal morbidity is hypertensive disorders of pregnancy (HDP), which includes preeclampsia, gestational hypertension, and chronic hypertension. Even though their immediate impacts on the health of the mother and the newborn are well known, there is now mounting evidence that they also have long-term consequences on the offspring's neurodevelopment and cognitive functioning.
Using data from clinical studies and new research, this study attempts to investigate the relationship between maternal hypertension during pregnancy and poor cognitive results in offspring. These mechanisms—placental insufficiency, oxidative stress, systemic inflammation, and epigenetic modifications—can all seriously impair the development of the fetal brain. These disturbances might show up as a higher prevalence of neurodevelopmental disorders like Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and intellectual disabilities, as well as lower IQ scores and subpar academic performance.
The review also examines the interactions between important variables, including gender, parity, childhood socioeconomic status, intrauterine growth restriction (IUGR), and preterm birth.
It has been demonstrated that children born to mothers with HDP, particularly preeclampsia, are more likely to experience behavioral and cognitive disorders, such as difficulties with memory, verbal thinking, and executive functioning. Moreover, anatomical and functional brain changes in the child have been linked to modifications in maternal cytokine profiles, stress hormone levels, and placental malfunction.
Targeted early interventions, better maternal health management, and early detection of at-risk pregnancies may help reduce negative outcomes despite these alarming correlations. The review emphasizes the significance of lifestyle changes, prenatal education, and additional research to create epigenetic markers for early screening. Raising understanding of HDP's cognitive effects is essential for guiding preventative pediatric efforts and enhancing the neurodevelopmental outcomes of impacted children for the rest of their lives.
Biography
Anuhya Katta has completed her MBBS from the University of Perpetual Help System Dalta, Jonelta Foundation School of Medicine, Philippines. With a strong academic and research background, she has a growing interest in internal medicine and pediatrics, particularly in the intersection between maternal health and child development. She has co-authored multiple research and review articles across a range of clinical topics including the efficacy of proton therapy in head and neck tumors, the use of tissue plasminogen activator in acute ischemic stroke, the influence of lifestyle factors on skin health, and the emerging role of stem cell therapy in regenerative medicine. Her most recent work on the impact of hypertensive disorders during pregnancy on offspring cognition has been published in the Hypertension Journal.
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