Azayeva Nurana Rafail GiziScientific-Research Institute of Cardiology , Azerbaijan
Title: The effect of three-component antihypertensive treatment on the structural and functional state of the heart and the daily blood pressure profile in patients with hypertension grade 3
The effect of treatment with the fixed combination drug Triplixam on the daily profile of blood pressure, the structural and functional state of the heart in 50 patients with hypertension Grade 3 has been evaluated. All patients have undergone clinical and laboratory-instrumental research (electrocardiography, Doppler echocardiography, daily monitoring of blood pressure ) at the beginning and after 6 months of treatment. Treatment with Triplixam has had a positive antihypertensive effect, which was achieved in the early stages of treatment and was more stable. Already after 3 months of treatment in the main group, 86% of patients achieved a decrease in systolic blood pressure of 20 mmHg or more and/or diastolic blood pressure by 10 mmHg, which persisted for 6 months. In the control group, despite a decrease in blood pressure, the target level after 6 months was achieved only in 18% of patients. After 6 months of treatment, an analysis of the results of daily monitoring of blood pressure has showed a decrease in average daily diastolic and systolic blood pressure by 15.9% and 18.6%, respectively. Variability of the average systolic and average diastolic pressures at night and day has been variable, which after treatment decreased statistically significantly by 4% and 4.2%, respectively. During treatment, an increase in the number of patients with a daily curve of the dipper type has been observed due to a decrease in non-dippers and night pickers. In patients of the main group, the carried out treatment has led to the achievement of an optimal reduction in the rate of morning rise in systolic and diastolic blood pressure. It has been also found a significant decrease in hypertrophy and sizes of the left ventricle, normalization of diastolic function of the left ventricle.
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