
Azayeva Nurana Rafail Gizi
Scientific-Research Institute of Cardiology, AzerbaijanTitle: The effect of three-component antihypertensive treatment on the structural and functional state of the heart and the daily blood pressure profile in patients with hypertension grade 3
Abstract
The effect of treatment
with the fixed combination drug Triplixam on the daily profile of blood
pressure, the structural and functional state of the heart in 50 patients with
hypertension Grade 3 has been evaluated. All patients have undergone clinical and
laboratory-instrumental research (electrocardiography, Doppler
echocardiography, daily monitoring of blood pressure ) at the beginning and
after 6 months of treatment. Treatment with Triplixam has had a positive
antihypertensive effect, which was achieved in the early stages of treatment
and was more stable. Already after 3 months of treatment in the main group, 86%
of patients achieved a decrease in systolic blood pressure of 20 mmHg or more
and/or diastolic blood pressure by 10 mmHg, which persisted for 6 months. In
the control group, despite a decrease in blood pressure, the target level after
6 months was achieved only in 18% of patients. After 6 months of treatment, an
analysis of the results of daily monitoring of blood pressure has showed a
decrease in average daily diastolic and systolic blood pressure by 15.9% and
18.6%, respectively. Variability of the average systolic and average diastolic
pressures at night and day has been variable, which after treatment decreased
statistically significantly by 4% and 4.2%, respectively. During treatment, an
increase in the number of patients with a daily curve of the dipper type has
been observed due to a decrease in non-dippers and night pickers. In patients
of the main group, the carried out treatment has led to the achievement of an
optimal reduction in the rate of morning rise in systolic and diastolic blood
pressure. It has been also found a significant decrease in hypertrophy and
sizes of the left ventricle, normalization of diastolic function of the left
ventricle.
Biography
Scientific-Research Institute of Cardiology names after acad. J.
Abdullayev, Azerbaijan, Baku