Systemic inflammation has been proven to be an important crucial factor during acute heart failure (AHF), with high levels of different inflammatory biomarkers identified in a relevant subset of patients. The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including heart failure, cardiovascular disease, and other autoimmune and autoinflammatory diseases. Specific natural structural biomolecules like Docosahexaenoic acid (DHA)/ Eicosapentaenoic acid (EPA) in the class of omega-3 long chain polyunsaturated fatty acids (PUFA) are well known anti-inflammatory agents. An ideal combination and ratio among those molecules including specific natural antioxidant vitamins could result in a preventive or vital holistic systems-medicine adjuvant therapeutic approach. How does that relate, among others, to the function of inflammasome. A thorough biomedical analysis of the pathways and the rationale might clarify the answer.

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