Dragan Novosel
Faculty of Medicine in Osijek, CroatiaTitle: Which is a better predictor of mortality in patients with heart failure - galectin 3 or SPPB (Short Physical Performance Battery)?
Abstract
We conducted a cohort study on 260 subjects
with heart failure who were hospitalized at the Department of Cardiovascular
Diseases of the Clinical Hospital Center Osijek for a period of 7 years. At
hospitalization, subjects were initially assigned functional status using the
SPPB (Short Physical Performance Battery) by clinicians, and mortality was
determined at the end of the five-year follow-up period. The median SPPB value
in surviving subjects was 4 with an interquartile range of 2 to 6, while the
median SPPB value of deceased subjects was 2 with an interquartile range of 2
to 4, with a P-value of 0.001 indicating a clear link between functional status
and mortality over a five-year period. The serum level of galectin-3 was
determined in 177 subjects. The SPPB did not show a statistically significant
correlation with the serum level of galectin-3 (P = 0.645). There was no
statistically significant difference in the serum value of galectin-3 between
the groups of deceased and survivors (P = 0.472). We can conclude that SPPB is
an excellent, affordable, and inexpensive measuring instrument for predicting
5-year mortality in patients with heart failure, and it is superior to
galectin-3 serum levels.
Biography
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