Elvin Allakhverdiev
National Medical Research Center of Cardiology , Russian FederationTitle: Possibility of evaluation of oxygen transport function in pah patients on effective selexipag-based therapy
Abstract
Idiopathic pulmonary hypertension (IPH) is a rare disease of the cardiovascular system, but the most common form of pulmonary arterial hypertension (PAH). Pathogenesis of idiopathic pulmonary arterial hypertension includes changes in biochemical and biophysical processes in various cell types. Hypoxia also plays an important role due to conformational changes in hemoglobin molecules with changes in their structure and oxygen transport function.
Aim: To study changes in the conformation of hemoglobin (Hb) to bind oxygen in blood of red blood cells from the cubital vein in IPAH patients and healthy volunteers using Raman spectroscopy.
Results: During our research we proved that the Raman spectra of Hb of whole blood and isolated red blood cells of IPAH patients have significant differences from the healthy volunteers. The IPAH group was characterized by an increase in the probability of finding heme in a «dome-shaped form», which is typical for the deoxygenated form of Hb. A significant role in the change in the oxygen-transport function of Hb in IPAH was played by a change in the conformation of membrane-bound hemoglobin. Also, as an opportunity to use Raman spectroscopy, we showed positive changes in spectroscopy parameters in a patient with the effective use of Selexipag.
Materials and methods: The study included 39 patients with newly diagnosed IPAH. 15 people did not receive PAH therapy. In 24 patients a “washout” period of trial therapy was conducted for 5–7 days. The control group included 10 healthy volunteers.
Conclusions: We have demonstrated of using a non-invasive method of Raman spectroscopy to study changes in the oxygen transport function of red blood cells in IPAH patients.
Biography
Elvin Allakhverdiev graduated from Lomonosov Moscow State University Faculty of Fundamental Medicine. Subsequently, he completed his residency in cardiology at the National Medical Research Center of Cardiology named after academician E.I. Chazov. During his studies, he published more than 10 articles in various high-ranking academic journals. He also participated as a speaker at various international conferences. In particular, he is the winner of the «Medal of the Russian Academy of Sciences with prizes for young scientists» in 2019. Elvin Allakhverdiev is also the holder of a patent for his invention of a method for predicting the severity of idiopathic pulmonary arterial hypertension. During his studies, he completed international internships at the University of Tsukuba Hospital and the University of Miami Miller School of Medicine. He is currently a postgraduate student of department of pulmonary hypertension and heart disease at the National Medical Research Center of Cardiology named after academician E.I. Chazov.
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