The purpose is to investigate the expediency of repeated irradiation of patients with different tumor localizations, taking into account the survival rates of patients, possible complications and subsequent quality of life. For the first time in Armenia, an analysis of the results of re-irradiation is carried out on the basis of the experience of one clinic. The results of treatment of 1645 patients who received radiotherapy at the IRA MEDICAL Group Radiotherapy Center from March 2019 to January 2023 were studied. The study included 64 patients who received a second course of RT, which accounted for 3.9% of total number of patients treated. The recruitment of patients was finished at December 2022. The final results of the study should be summarized at the end of the 2023, after one year follow-up. The average life expectancy of patients who died during the observation period was 6.5 months (1-23). In 8 out of 64 patients who initially had low KPS (60%), survival was up to 3.5 months or less. After excluding these patients from further statistical analysis, the median survival of the remaining patients was 10 months (4 – 23). As of December 31, 2022, 38 patients (60.9%) are alive, with an average follow-up of 15 months (5 – 31.5). The number of post-radiation complications and the quality of life of patients were also assessed. The results of this prospective study demonstrate that the use of the latest technologies in repeat radiotherapy can improve survival and quality of life in these patients. Thanks to new technologies, it is possible to conduct a repeated course of radiotherapy even in curative doses.

Nerses Karamyan has completed his Ph.D. in the 2016. He is the Professor of Oncology Department in the National Institute of Health of Armenia. Also, he is working as the Senior Radiation Oncologist in the IRA Medical Group Radiotherapy Center, Yerevan, Armenia. He has over 100 publications that have been mentioned over 100 times.