Tatyana BarysenkaGrodno State Medical University, Belarus
Title: The correlation between hyperuricemia and cardiac remodeling in patients with hypertension and atrial fibrillation
Background: Cardiovascular diseases occupy a leading place in the overall structure of morbidity, disability and mortality of the population in many countries. The risk of developing atrial fibrillation (AF) increases in the presence of structural changes in the myocardium. Hyperuricemia (HU) is a proven cardiovascular risk factor. An increase serum uric acid (SUA) level is increasingly associated not only with the possible risk of such a classic disease as gout, but also with such pathological processes as hypertension (HTN) and AF.
The aim of the study is to assess the correlation between SUA level and myocardial remodeling in patients with HTN and AF.
Material and methods: The study included 104 patients with HTN and/or AF at the age under 65 years, 94 (90,4%) were male. The SUA level was determined by an enzymatic colorimetric method.
Results: High SUA level was revealed in 31.7% of 104 patients. The patients with persistent and permanent AF had higher uricemia than the ones with paroxysmal AF. The patients with HU were more likely to have permanent (33.3%) and persistent (39.4%) AF. A significant correlation was found between elevated UA level and left atrial dilatation (LAD) (U=1616,0, p=0,002, rrb=-0,379). LAD was significantly more common in patients with HU – 18 (54.5%) cases than in patients with normal SUA level. In the patients with HU, the left atrial volume index was significantly higher compared to those with normal SUA level – 42 [39; 44] mL/m2 and 38 [36; 42] mL/m2, respectively (p=0.002). In patients with HU, the left ventricle ejection fraction was significantly lower compared to those with a normal SUA level – 60 [57; 65]% and 64 [61; 67]% respectively (U=831.0, p=0.02, rrb=0.291).
Conclusion: HU occurs in 31.7% of patients with HTN and AF and associated with cardiac remodeling
Tatyana Barysenka graduated from Grodno State Medical University in 2013, as a Medical Doctor, with the specialty of Internal Medicine. Later become assistant of professor of Grodno State Medical University, Belarus. Author of more than 20 scientific papers. Scientific research is devoted to the problems of treating arterial hypertension and heart rhythm disturbances.