
Tomoo Harada
St. Marianna University School of Medicine, JapanPresentation Title:
Epicardial radiofrequency ablation of ventricular tachycardia that shared a pathway with bi-directional conduction in a patient with human immunodeficiency virus-associated cardiomyopathy
Abstract
Despite the widespread use of antiretroviral therapy, Human Immunodeficiency Virus (HIV)-Associated Cardiomyopathy (HIVAC) remains a significant cause of morbidity and mortality due to lethal arrhythmias Ventricular Tachycardia (VT) and ventricular fibrillation and worsening heart failure. HIV infects myocardial cells in a patchy distribution and stimulates myocardial dendritic cells, which in turn activate multifunctional cytokines and an inducible form of nitric oxide synthase. This contributes to progression and leads to late stages of myocardial tissue damage. Cardiac Magnetic Resonance Imaging (MRI) findings have demonstrated that patients with myocarditis had late gadolinium enhancement localized to the sub-epicardial regions of the LV extending to various degrees through the ventricular wall. A 59-year-old man who had been diagnosed with human immunodeficiency virus-associated cardiomyopathy was referred for catheter ablation of VT. An Electrocardiogram (ECG) waveform revealed that the clinical VT originated from the epicardium. A Deceleration Zone (DZ) was identified on an isochronal late activation map. Moreover, 2 forms of monomorphic VT were induced by different cycle length burst pacings from near the DZ. The morphologies of the 2 VTs with an identical cycle length were very likely to use a shared common pathway with bidirectional conduction around the slow conduction area in the left ventricle posterolateral small epicardial surface area. After ablation of the DZ, the VT was uninducible.
Biography
Professional training and employment:
2013-present Professor, department of cardiology, St. marianna University School of Medicine, director of Heart Center, St. Marianna University Hospital.
2008-2012 Associate professor, St. Marianna University School of Medicine.
1994-1996 Research fellow Harvard Medical School Brigham and Women`s Hospital.
1983-1994 Resident and medical stuff, internal medicine, St. Marianna University Toyoko Hospital.
1983 Passed the Examination of National Board.
Teaching Experience
2000-present clinical cardiology course for medical students.
Membership
The Japanese Society of Internal Medicine, The Japanese Circulation Society, The Japanese Heart Rhythm Society, the Japanese College of Cardiology and Asia Pacific Heart Rhythm Society (APHRS).
Board Certification
Board Certified Member of the Japanese Society of Internal Medicine 1992, Board Certified Member of the Japanese Circulation Society 1998, Board Certified Member of the Japanese Heart Rhythm Society 2012.